Formulation of Mucoadhesive Tablets with Fully Gelatinized Modified Daluga (Cyrtosperma Merkusii) Matrix Using Simplex Lattice Design Method


  • I Gusti Ngurah Agung Dewantara Putra Universitas Udayana, Indonesia
  • Made Krisna Adi Jaya Universitas Udayana, Indonesia



mucoadhesive tablets, gelatinized modified daluga (cyrtosperma merkusii), simplex lattice design method


starch could used as ingredient fillers, binders and crushers in tablet manufacture. Amylum is also defined as carbohydrates from from plant, as results photosynthesis, which is stored in part certain plant as backup food starch is mixture two type structure different polysaccharides that is contains (17-20) % amylose and (80-83) % amylopectin. Destination study this is for know the formulation of mucoadhesive tablets with fully gelatinized modified daluga (cyrtosperma merkusii) matrix using simplex lattice design method. Quantitative Test Methods that aim for count yield starch and qualitative tests aimed at for knowing content polysaccharides in starch. Iodine test on amylose will show color blue, and on amylopectin. Character test result data physique granules and tablets as well as release ranitidine of tablets analyzed with using the Design-Expert® software, so that obtained the contour plot of each test results. Determination of the optimum formula begins with determine the optimized parameters that is speed flow, tablet hardness, tablet friability, floating time and speed release ranitidine HCl