A Comparison of the Accuracy of the Kagoshima Score and the Wells Score in Predicting Suprainguinal Deep Vein Thrombosis at Dr. Cipto Mangunkusumo National General Hospital
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Background: Suprainguinal deep vein thrombosis (DVT) is a thrombotic condition associated with serious complications such as pulmonary embolism and post-thrombotic syndrome. The clinical manifestations of suprainguinal DVT are often nonspecific, making early diagnosis challenging, particularly in healthcare facilities with limited access to vascular imaging modalities. Wells Score and Kagoshima Score are clinical scoring systems used to increase the probability of DVT detection; however, their performance in suprainguinal DVT has not been widely evaluated. Methods: This study was a retrospective medical record-based study involving patients with CTA-confirmed suprainguinal DVT at Dr. Cipto Mangunkusumo National General Hospital. Data collected included demographic characteristics, thrombotic risk factors, clinical manifestations, Wells Score, and Kagoshima Score. Analyses were performed to evaluate the sensitivity of both scores and factors associated with false-negative predictions. Results: A total of 47 patients with CTA-confirmed suprainguinal DVT were included in this study. Most subjects were female, with a mean age above 50 years. The most common clinical manifestation was lower limb edema (95.7%), followed by superficial venous dilatation and lower extremity pain. Kagoshima Score demonstrated a sensitivity of 91.5%, whereas Wells Score showed a sensitivity of 89.4%. Bivariate analysis revealed that younger age and absence of cancer history were significantly associated with false-negative predictions in both scoring systems. In addition, lower BMI was associated with false-negative prediction in Wells Score. All patients with a history of malignancy were successfully classified as high-risk by both scores.
Bagot, C. N., & Arya, R. (2008). Virchow and his triad: A question of attribution. British Journal of Haematology. https://doi.org/10.1111/j.1365-2141.2008.07323.x
Branchford, B. R., & Carpenter, S. L. (2018). The role of inflammation in venous thromboembolism. Frontiers in Pediatrics. https://doi.org/10.3389/fped.2018.00142
Ciccotosto, C., Goodman, L. R., Washington, L., & Quiroz, F. A. (2002). Indirect CT venography following CT pulmonary angiography: Spectrum of CT findings. Journal of Thoracic Imaging. https://doi.org/10.1097/00005382-200201000-00002
Goodacre, S., Sampson, F., Thomas, S., van Beek, E., & Sutton, A. (2005). Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis. BMC Medical Imaging, 5. https://doi.org/10.1186/1471-2342-5-6
Grigorian, A., & Nahmias, J. T. (2023). Upper extremity deep venous thrombosis. In StatPearls. StatPearls Publishing.
Guyatt, G. H., Norris, S. L., Schulman, S., Hirsh, J., Eckman, M. H., & Akl, E. A. (2012). Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines. Chest, 141(2). https://doi.org/10.1378/chest.11-2288
Hamamoto, Y., Tokushige, A., Toshinori, Y., Ikeda, Y., Horizoe, Y., & Yasuda, H. (2022). A new pre-test probability score for diagnosis of deep vein thrombosis in patients before surgery. Journal of Cardiology, 79(5). https://doi.org/10.1016/j.jjcc.2021.11.025
Huang, Y., Ge, H., Wang, X., & Zhang, X. (2022). Association between blood lipid levels and lower extremity deep venous thrombosis: A population-based cohort study. Clinical and Applied Thrombosis/Hemostasis, 28. https://doi.org/10.1177/10760296221121282
Kakkos, S. K., Gohel, M., Baekgaard, N., Bauersachs, R., Bellmunt-Montoya, S., & Black, S. A. (2021). Editor’s Choice – European Society for Vascular Surgery (ESVS) 2021 clinical practice guidelines on the management of venous thrombosis. European Journal of Vascular and Endovascular Surgery, 61(1). https://doi.org/10.1016/j.ejvs.2020.09.023
Kearon, C., Julian, J. A., Newman, T. E., & Ginsberg, J. S. (1998). Noninvasive diagnosis of deep venous thrombosis. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-128-8-199804150-00011
Kumar, D. R., Hanlin, E. R., Glurich, I., Mazza, J. J., & Yale, S. H. (2010). Virchow’s contribution to the understanding of thrombosis and cellular biology. Clinical Medicine & Research, 8(3–4). https://doi.org/10.3121/cmr.2009.866
Langford, N. J., Stansby, G., & Avital, L. (2012). The management of venous thromboembolic diseases and the role of thrombophilia testing: Summary of NICE guideline CG144. Acute Medicine. https://doi.org/10.52964/amja.0562
Lewis, T. C., Cortes, J., Altshuler, D., & Papadopoulos, J. (2019). Venous thromboembolism prophylaxis: A narrative review with a focus on the high-risk critically ill patient. Journal of Intensive Care Medicine. https://doi.org/10.1177/0885066618796486
McLendon, K., Goyal, A., & Attia, M. (2021). Deep venous thrombosis risk factors. In StatPearls. StatPearls Publishing.
Min, S. K., Kim, Y. H., Joh, J. H., Kang, J. M., Park, U. J., & Kim, H. K. (2016). Diagnosis and treatment of lower extremity deep vein thrombosis: Korean practice guidelines. Vascular Specialist International, 32(3). https://doi.org/10.5758/vsi.2016.32.3.77
Modi, S., Deisler, R., Gozel, K., Reicks, P., Irwin, E., & Brunsvold, M. (2016). Wells criteria for DVT is a reliable clinical tool to assess the risk of deep venous thrombosis in trauma patients. World Journal of Emergency Surgery, 11(1). https://doi.org/10.1186/s13017-016-0078-1
Naringrekar, H., Sun, J., Ko, C., & Rodgers, S. K. (2019). It’s not all deep vein thrombosis: Sonography of the painful lower extremity with multimodality correlation. Journal of Ultrasound in Medicine. https://doi.org/10.1002/jum.14776
Rabinov, K., & Paulin, S. (1972). Roentgen diagnosis of venous thrombosis in the leg. Archives of Surgery, 104(2). https://doi.org/10.1001/archsurg.1972.04180020014004
Sarshar, S., Khan, M. B., Muhammad, D., Sanaullah, Parveen, I., & Sarfaraz, S. (2025). Accuracy of Doppler USG assessment of lower extremity peripheral arterial disease using CTA as gold standard. Biological and Clinical Sciences Research Journal, 6(5), 152–155. https://doi.org/10.54112/bcsrj.v6i5.1773
Stevens, S. M., Woller, S. C., Kreuziger, L. B., Bounameaux, H., Doerschug, K., & Geersing, G. J. (2021). Antithrombotic therapy for VTE disease: Second update of the CHEST guideline and expert panel report. Chest, 160(6). https://doi.org/10.1016/j.chest.2021.07.055
Stone, J., Hangge, P., Albadawi, H., Wallace, A., Shamoun, F., & Knuttien, M. G. (2017). Deep vein thrombosis: Pathogenesis, diagnosis, and medical management. Cardiovascular Diagnosis and Therapy. https://doi.org/10.21037/cdt.2017.09.01
Stubbs, M. J., Mouyis, M., & Thomas, M. (2018). Deep vein thrombosis. BMJ, 360, k351. https://doi.org/10.1136/bmj.k351
Tambunan, K. L., Kurnianda, J., Suharti, C., Wardhani, S. O., Sukrisman, L., & Soetandyo, N. (2020). IDENTIA Registry: Incidence of deep vein thrombosis in medically ill subjects at high risk in Indonesia: A prospective study. Acta Medica Indonesiana, 52(1), 14. https://www.actamedindones.org/index.php/ijim/article/view/1239
Virchow’s triad and deep vein thrombosis (DVT). (2025). In Calgary Guide. https://calgaryguide.ucalgary.ca/virchows-triad-and-deep-vein-thrombosis-dvt/
Waheed, S. M., Kudaravalli, P., & Hotwagner, D. T. (2023). Deep venous thrombosis. In StatPearls. StatPearls Publishing.
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