The Relationship Between Polyunsaturated Fatty Acid (PUFA) Intake and Cognitive Function in Psychiatric Patients with Depressive Disorders

Authors

  • Erlansa Budiyoga Universitas Diponegoro
  • Linda Kartikasari Universitas Diponegoro
  • Natalia Dewi Wardani Universitas Diponegoro

DOI:

https://doi.org/10.59188/eduvest.v6i3.52919

Keywords:

Depression, PUFA, MoCa- Ina

Abstract

Disturbance depressive is a mental health disorder that is often associated with cognitive decline. Nutrition, particularly polyunsaturated fatty acid (PUFA) intake, is thought to play a role in maintaining brain health and cognitive function. However, evidence of a link between PUFA intake and cognitive function as measured by the Montreal Cognitive Assessment (MoCA)Indonesian version (MoCA-Ina), in patients with depressive disorders remains limited. This study aims to evaluate the relationship between PUFA intake and cognitive function in psychiatric patients with depressive disorders. This was an analytical study using secondary data from patients with depressive disorders at Dr. Kariadi General Hospital, Diponegoro National Hospital, Banyumanik Hospital 1, and Elisabeth Hospital Semarang from May 2022 to 2023. The study included patients aged 18–60 years who were diagnosed with depressive disorders, had completed the Food Frequency Questionnaire (FFQ) and MoCA-Ina assessments, and had no serious physical illness or metabolic syndrome. The analysis used the Spearman correlation test to assess the relationship between PUFA intake and cognitive function, as well as the Mann–Whitney test for comparisons based on PUFA intake categories. A total of 30 patients with depressive disorders were included, of whom 83.3% were female, with a mean age of 26.03 years. The mean PUFA intake was 6.31 grams, and the mean MoCA-Ina score was 27.67. The Spearman test showed no significant association between PUFA intake and cognitive function (p = 0.790). There was no significant relationship between PUFA intake and cognitive function in patients with depressive disorders.

References

Appleton, K. M., Voyias, P. D., Sallis, H. M., Dawson, S., Ness, A. R., Churchill, R., & Perry, R. (2021). Omega-3 fatty acids for depression in adults. Cochrane Database of Systematic Reviews, 2021(11), CD004692. https://doi.org/10.1002/14651858.CD004692.pub5

Bafkar, N., Zeraattalab-Motlagh, S., Jayedi, A., & Shab-Bidar, S. (2024). Efficacy and safety of omega-3 fatty acids supplementation for anxiety symptoms: A systematic review and dose-response meta-analysis of randomized controlled trials. BMC Psychiatry, 24(1), 455. https://doi.org/10.1186/s12888-024-05881-2

Cheng, Y. C., Chen, W. Y., Lin, C., Lee, S. H., Chiu, C. C., & Kuo, P. H. (2025). The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. Journal of Affective Disorders, 369, 8–15. https://doi.org/10.1016/j.jad.2024.09.129

Cohen Kadosh, K., Muhardi, L., Parikh, P., Basso, M., Jan Mohamed, H. J., & Prawitasari, T. (2021). Nutritional support of neurodevelopment and cognitive function in infants and young children—An update and novel insights. Nutrients, 13(1), 199. https://doi.org/10.3390/nu13010199

Deane, K. H. O., Jimoh, O. F., Biswas, P., O’Brien, A., Hanson, S., & Abdulhamid, U. S. (2021). Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: Systematic review and meta-analysis of randomized trials. The British Journal of Psychiatry, 218(3), 135–142. https://doi.org/10.1192/bjp.2019.234

Delpech, J. C., Madore, C., Joffre, C., Aubert, A., Kang, J. X., Nadjar, A., & Layé, S. (2020). n-3 polyunsaturated fatty acids and their derivates reduce neuroinflammation during aging. Nutrients, 12(3), 647. https://doi.org/10.3390/nu12030647

Dyall, S. C., Bazan, N. G., Brenna, J. T., Chiang, N., & da Costa Souza, F. (2022). Polyunsaturated fatty acids and lipid-derived mediators: Recent advances in their biosynthesis, structures, and functions. Progress in Lipid Research, 86, 101165. https://doi.org/10.1016/j.plipres.2022.101165

Firth, J., Teasdale, S. B., Allott, K., Siskind, D., Marx, W., & Cotter, J. (2019). The efficacy and safety of nutrient supplements in the treatment of mental disorders: A meta-review of meta-analyses of randomized controlled trials. World Psychiatry, 18(3), 308–324. https://doi.org/10.1002/wps.20672

Gui, Y., He, D., Li, J., & Zhao, H. (2024). Omega-3 PUFAs’ efficacy in the therapy of coronary artery disease combined with anxiety or depression: A meta-analysis. Frontiers in Psychiatry, 15, 1368007. https://doi.org/10.3389/fpsyt.2024.1368007

Li, Y., Li, S., Money, W., & Zhang, D. (2020). Association between dietary protein intake and cognitive function in adults aged 60 years and older. Journal of Nutrition, Health & Aging, 24(2), 223–229. https://doi.org/10.1007/s12603-019-1319-4

Liao, Y., Xie, B., Zhang, H., He, Q., Guo, L., Subramaniapillai, M., Fan, B., Lu, C., & McIntyre, R. S. (2021). Efficacy of omega-3 PUFAs in depression: A meta-analysis. Translational Psychiatry, 11(1), 465. https://doi.org/10.1038/s41398-021-01582-6

Melo, H. M., Santos, L. E., & Ferreira, S. T. (2019). Diet-derived fatty acids, brain inflammation, and mental health. Frontiers in Neuroscience, 13, 265. https://doi.org/10.3389/fnins.2019.00265

Okereke, O. I., Vyas, C. M., Mischoulon, D., Chang, G., Cook, N. R., Weinberg, A., Bubes, V., Copeland, T., Friedenberg, G., Lee, I. M., Buring, J. E., Reynolds, C. F., & Manson, J. E. (2021). Effect of long-term supplementation with marine omega-3 fatty acids vs placebo on risk of depression or clinically relevant depressive symptoms and on change in mood scores: A randomized clinical trial. JAMA, 326(23), 2385–2394. https://doi.org/10.1001/jama.2021.21187

Pan, Z., Park, C., Brietzke, E., Zuckerman, H., Rong, C., & Mansur, R. B. (2019). Cognitive impairment in major depressive disorder. CNS Spectrums, 24(1), 22–29. https://doi.org/10.1017/S1092852918001207

Puri, S., Shaheen, M., & Grover, B. (2023). Nutrition and cognitive health: A life course approach. Frontiers in Public Health, 11, 1023907. https://doi.org/10.3389/fpubh.2023.1023907

Roberts, M., Tolar-Peterson, T., Reynolds, A., Wall, C., Reeder, N., & Rico Mendez, G. (2022). The effects of nutritional interventions on the cognitive development of preschool-age children: A systematic review. Nutrients, 14(3), 532. https://doi.org/10.3390/nu14030532

Thapar, A., Eyre, O., Patel, V., & Brent, D. (2022). Depression in young people. The Lancet, 400(10352), 617–631. https://doi.org/10.1016/S0140-6736(22)01011-4

Wolters, M., von der Haar, A., Baalmann, A. K., Wellbrock, M., Heise, T. L., & Rach, S. (2021). Effects of n-3 polyunsaturated fatty acid supplementation in the prevention and treatment of depressive disorders: A systematic review and meta-analysis. Nutrients, 13(4), 1070. https://doi.org/10.3390/nu13041070

Wu, S. K., Yang, K. J., & Liu, W. C. (2024). The efficacy of omega-3 fatty acids as the monotherapy for depression: A randomized, double-blind, placebo-controlled pilot study. Nutrients, 16(21), 3688. https://doi.org/10.3390/nu16213688

Xu, C., Bi, S., Zhang, W., & Luo, L. (2024). The effects of creatine supplementation on cognitive function in adults: A systematic review and meta-analysis. Frontiers in Nutrition, 11, 1424972. https://doi.org/10.3389/fnut.2024.1424972

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Published

2026-03-19

How to Cite

Budiyoga, E., Kartikasari, L. ., & Dewi Wardani, N. . (2026). The Relationship Between Polyunsaturated Fatty Acid (PUFA) Intake and Cognitive Function in Psychiatric Patients with Depressive Disorders. Eduvest - Journal of Universal Studies, 6(3), 3783–3790. https://doi.org/10.59188/eduvest.v6i3.52919