Male Androgenetic Alopecia Treated with Single Spin Platelet Rich Plasma: A Case Report
DOI:
https://doi.org/10.59188/eduvest.v5i11.52334Keywords:
Platelet-Rich Plasma, Androgenetic Alopecia, MaleAbstract
Androgenetic alopecia (AGA) is the most common type of hair loss, causing gradual, progressive miniaturization of hair follicles and shortening of the anagen phase in genetically predisposed men and women, following a distinct pattern. Hair loss usually begins after puberty and is more prevalent in men. This case report details a young male patient with androgenetic alopecia treated with single spin platelet-rich plasma (PRP) therapy combined with topical minoxidil. A 27-year-old Minahasan male experienced hair thinning and loss for 10 years, starting at the middle of his head and spreading outward. Examination showed thinning at the fronto-parietal hairline and vertex, classified as Hamilton-Norwood III vertex. Treatment involved biweekly single spin PRP injections and twice-daily application of 5% topical minoxidil. The PRP was prepared by centrifugation at 3000 rpm for 15 minutes, with up to nine sessions administered. Clinical evaluations through hair pull tests and trichoscopy revealed significant improvement, including increased hair density and changes in follicle diameter in treated areas. By week eighteen, hair density increased markedly, and hair loss diminished without side effects. The patient was highly satisfied with the cosmetic results. This case report indicates that single spin PRP combined with topical minoxidil is an effective, safe, and reliable treatment for male androgenetic alopecia, offering clinical improvement and enhanced hair growth without adverse effects. The simplified PRP protocol provides practical advantages for clinical use, especially in resource-limited settings, and supports growing evidence for PRP as an adjunct therapy for androgenetic alopecia in young Asian patients.
References
Anastassakis, Konstantinos. (2022). Diet, Lifestyle, and AGA/FPHL. In Androgenetic Alopecia From A to Z: Vol. 2 Drugs, Herbs, Nutrition and Supplements (pp. 255–267). Springer.
Guo, Rui Xian, Zhao, Yong Kang, Hu, Ke Jian, Jia, Kun Mu, Shi, Wei, Yi, Yan Xiao, Gong, Hai Ying, Wang, Jia Bo, & Gao, Yuan. (2025). Research progress in the treatment of non-scarring alopecia: mechanism and treatment. Frontiers in Pharmacology, 16, 1544068.
Gupta, Aditya K., Talukder, Mesbah, & Williams, Greg. (2022). Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia. Journal of Dermatological Treatment, 33(7), 2946–2962.
Gupta, Sanjeev, Goyal, Ishan, & Mahendra, Aneet. (2019). Quality of life assessment in patients with androgenetic alopecia. International Journal of Trichology, 11(4), 147–152.
Ho, Chih Yi, Chen, Jeff Yi Fu, Hsu, Wen Li, Yu, Sebastian, Chen, Wei Chiao, Chiu, Szu Hao, Yang, Hui Ru, Lin, Sheng Yao, & Wu, Ching Ying. (2023). Female pattern hair loss: an overview with focus on the genetics. Genes, 14(7), 1326.
Huang, Chun Hsien, Fu, Yun, & Chi, Ching Chi. (2021). Health-related quality of life, depression, and self-esteem in patients with androgenetic alopecia: a systematic review and meta-analysis. Jama Dermatology, 157(8), 963–970.
Kidangazhiathmana, Ajithkumar, & Santhosh, Parvathy. (2022). Pathogenesis of androgenetic alopecia. Clinical Dermatology Review, 6(2), 69–74.
Lee, Sung Won, Juhasz, Margit, Mobasher, Pezhman, Ekelem, Chloe, & Mesinkovska, Natasha Atanaskova. (2018). A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women. Journal of Drugs in Dermatology: JDD, 17(4), 457.
Legiawati, Lili, Yusharyahya, Shannaz Nadia, Bernadette, Irma, Novianto, Endi, Priyanto, Mufqi Handaru, Gliselda, Keneyzia Carla, Iriyanty, Septiana, & Mutiara, Rizka. (2023). Comparing single-spin versus double-spin platelet-rich plasma (PRP) centrifugation methods on thrombocyte count and clinical improvement of androgenetic alopecia: a preliminary, randomized, double-blind clinical trial. The Journal of Clinical and Aesthetic Dermatology, 16(12), 39.
Lopes-Silva, Rúben, Santos, Maria, Sequeira, Maria Luísa, Silva, Andreia, Antunes, Tatiana, Valejo-Coelho, Paulo, Neiva-Sousa, Manuel, & Silva Sr, Rúben. (2025). Platelet-Rich Plasma Effectiveness in Treating Androgenetic Alopecia: A Comprehensive Evaluation. Cureus, 17(1).
McCarthy, Ashley. (2024). A qualitative exploration of Alopecia: impact, coping and interactions with professionals.
Mishra, Prabhu Chandra, Gupta, Saurabh K., Jha, Saurabh Kumar, Sharma, Radhey Shyam, Arora, Mohini, & Verma, Chaitenya. (2025). Optimising Platelet Rich Plasma Preparation: Investigating the Effects of Temperature on platelet viability and growth factor release. Vascular and Endovascular Review, 8(7s), 127–133.
Nguyen, Lam Van, & Nguyen, Trang Thi Thuy. (2025). Effectiveness of Autologous Platelet-Rich Plasma for Androgenetic Alopecia: A Double-Center, Non-Controlled, Randomized Clinical Study in Vietnam. Clinical, Cosmetic and Investigational Dermatology, 1645–1656.
Oiwoh, Sebastine Oseghae, Enitan, Ademola Olusegun, Adegbosin, Olubola Titilope, Akinboro, Adeolu Oladayo, & Onayemi, Emmanuel Olaniyi. (2024). Androgenetic alopecia: A review. Nigerian Postgraduate Medical Journal, 31(2), 85–92.
Pyles, Malcolm, Seck, Sokhna, & Khetarpal, Shilpi. (2025). Populations of South Asian ancestry. In Cosmetic Procedures in Skin of Color (pp. 70–82). Elsevier.
Qian, Qili, Gu, Yuanping, Luo, Junyu, Wu, Sijie, Li, JiaPeng, Li, Jinxi, Peng, Qianqian, Chen, Wenyan, Yang, Yajun, & Wang, Jiucun. (2025). Genetic and environmental factors affecting hair density in East Asian populations. British Journal of Dermatology, ljaf149.
Saqlain, Nazish, Mazher, Naghmana, Fateen, Tooba, & Siddique, Asma. (2023). Comparison of single and double centrifugation methods for preparation of Platelet-Rich Plasma (PRP). Pakistan Journal of Medical Sciences, 39(3), 634.
Sidarta, Erick, Sari, Triyana, Nataprawira, Sari Mariyati Dewi, Andianto, Ivan Christian, & Sajiwo, Damar. (2024). The Role of rs6152 Allele and Non-Genetic Factors in Androgenetic Alopecia: A Pilot Study in the Indonesian Local Population. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 8(6), 447–4476.
Sinikumpu, Suvi Päivikki, Jokelainen, Jari, Auvinen, Juha, Timonen, Markku, & Huilaja, Laura. (2021). Association between psychosocial distress, sexual disorders, self-esteem and quality of life with male androgenetic alopecia: a population-based study with men at age 46. BMJ Open, 11(12), e049855.
Vrapcea, Adelina, Pisoschi, Cătălina Gabriela, Ciupeanu-Calugaru, Eleonora Daniela, Traşcă, Emil Tiberius, Tutunaru, Cristina Violeta, Rădulescu, Patricia Mihaela, & Rădulescu, Dumitru. (2025). Inflammatory Signatures and Biological Markers in Platelet-Rich Plasma Therapy for Hair Regrowth: A Comprehensive Narrative Analysis. Diagnostics, 15(9), 1123.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Anggi Anastasia Ursula Dien, Ferra Olivia Mawu, Aryani Adji, William Yudistha Anggawirya, Paulus Mario Christopher
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
