Antidiabetic Activity Of Barley Porridge On Postprandial Blood Glucose And Histopathology Of Alloxan-Induced Diabetics Rats
DOI:
https://doi.org/10.59188/eduvest.v4i11.39006Keywords:
Barley, Diabetic, Phytochemicals, Pancreas HistopathologyAbstract
Diabetes mellitus (DM) is a critical global health issue, characterized by high morbidity and mortality rates associated with various complications. In Indonesia, the incidence is projected to reach 28.6 million by 2045, positioning the country among the highest globally. The aim of this study is to evaluate the effects of barley as a food ingredient on blood sugar levels and pancreatic histopathology. The study involved dividing the mice into six groups, with six mice in each group. These groups were: normal control (K), negative control (KN) induced with alloxan 125 mg/kg BW intraperitoneally, positive control (KP) with oral metformin 9 mg/200 g BW, normal barley rats (P1), DM barley rats (P2), and DM rats with mixed food (P3). Phytochemical screening was also conducted on barley porridge to identify the presence of flavonoids, glycosides, alkaloids, and saponins. The KP and P2 groups were more effective in reducing blood sugar levels than the KN and P3 groups. In the Kruskal-Wallis test, there was no significant difference between groups P2 and KP on postprandial blood sugar levels, indicating that barley produced an effect similar to metformin (p-value = 0.0395). Pancreatic histopathology observations showed that groups P2, P3, and KP had the same damage score of 2. Barley demonstrated a comparable antidiabetic effect to metformin, as evidenced by similar results in blood sugar reduction and pancreatic histopathology scores in the P2 and KP groups
References
Ahuja, A., Gupta, J., & Gupta, R. (2020). Diabetes Silent Killer: Medical Focus On Food Replacement And Dietary Plans. Adv Biores, 11(5), 128–135.
Azam, A., Itrat, N., & Ahmed, U. (2019). Hypoglycemic Effect Of Barley (Hordeum Vulgare) In Diabetics. Int. J. Innov. Sci. Res. Technol, 4, 165–168.
Bibi, C., & Husain, S. (2024). A Comprehensive Review On Medicinal Properties, Phytochemistry, And Pharmacology Of Hordeum Vulgare Linn: An Important Plant Origin Unani Drug. Journal Of Pharmacognosy And Phytochemistry, 13(3), 132–139.
Boanta, E.-A., Muntean, L., Russu, F., Ona, A. D., Porumb, I., & Filip, E. (2019). Barley (Hordeum Vulgare L.): Medicinal And Therapeutic Uses-Review.
Bohl, M., Gregersen, S., Zhong, Y., Hebelstrup, K. H., & Hermansen, K. (2024). Beneficial Glycaemic Effects Of High-Amylose Barley Bread Compared To Wheat Bread In Type 2 Diabetes. European Journal Of Clinical Nutrition, 78(3), 243–250.
Calderon Guzman, D., Juárez Olguín, H., Veloz Corona, Q., Ortiz Herrera, M., Osnaya Brizuela, N., & Barragán Mejía, G. (2020). Consumption Of Cooked Common Beans Or Saponins Could Reduce The Risk Of Diabetic Complications. Diabetes, Metabolic Syndrome And Obesity, 3481–3486.
Fuse, Y., Higa, M., Miyashita, N., Fujitani, A., Yamashita, K., Ichijo, T., Aoe, S., & Hirose, T. (2020). Effect Of High Β-Glucan Barley On Postprandial Blood Glucose And Insulin Levels In Type 2 Diabetic Patients. Clinical Nutrition Research, 9(1), 43–51.
Ham, J. R., Son, Y.-J., Lee, Y., Lee, H.-J., Yeo, J., Lee, M. J., & Lee, M.-K. (2022). Korean Naked Waxy Barley (Saechalssal) Extract Reduces Blood Glucose In Diabetic Mice By Modulating The PI3K-Akt-GSK3β Pathway. Biomedicine & Pharmacotherapy, 150, 112976.
Hamany Djande, C. Y., & Dubery, I. A. (2024). Hordatines, Dimerised Hydroxycinnamoylagmatine Conjugates Of Barley (Hordeum Vulgare L.): An Appraisal Of The Biosynthesis, Chemistry, Identification And Bioactivities. Phytochemistry Reviews, 1–18.
Hwalla, N., Jaafar, Z., & Sawaya, S. (2021). Dietary Management Of Type 2 Diabetes In The MENA Region: A Review Of The Evidence. Nutrients, 13(4), 1060.
Idehen, E., Wang, W., & Sang, S. (2020). Health Benefits Of Barley For Diabetes. Journal Of Food Bioactives, 12.
Lestari, L., & Zulkarnain, Z. (2021). Diabetes Melitus: Review Etiologi, Patofisiologi, Gejala, Penyebab, Cara Pemeriksaan, Cara Pengobatan Dan Cara Pencegahan. Prosiding Seminar Nasional Biologi, 7(1), 237–241.
Mahajan, R., Prasad, S., Gaikwad, S., & Itankar, P. (2023). Antioxidant Phenolic Compounds From Seeds Of Hordeum Vulgare Linn. Ameliorates Diabetic Nephropathy In Streptozotocin-Induced Diabetic Rats. Journal Of Traditional Chinese Medical Sciences, 10(3), 353–361.
Milita, F., Handayani, S., & Setiaji, B. (2021). Kejadian Diabetes Mellitus Tipe II Pada Lanjut Usia Di Indonesia (Analisis Riskesdas 2018). Jurnal Kedokteran Dan Kesehatan, 17(1), 9–20.
Minaiyan, M., Ghannadi, A., Movahedian, A., & Hakim-Elahi, I. (2014). Effect Of Hordeum Vulgare L.(Barley) On Blood Glucose Levels Of Normal And STZ-Induced Diabetic Rats. Research In Pharmaceutical Sciences, 9(3), 173–178.
Organization, W. H. (2019). Classification Of Diabetes Mellitus.
Pino, J. L., Mujica, V., & Arredondo, M. (2021). Effect Of Dietary Supplementation With Oat Β-Glucan For 3 Months In Subjects With Type 2 Diabetes: A Randomized, Double-Blind, Controlled Clinical Trial. Journal Of Functional Foods, 77, 104311.
PRATAMA, R. Y., PRANITASARI, N., & PURWANINGSARI, D. (2020). Pengaruh Ekstrak Daun Sirsak Terhadap Gambaran Histopatologi Pankreas Rattus Norvegicus Jantan Yang Diinduksi Aloksan. Hang Tuah Medical Journal, 17(2), 116–129.
Promyos, N., Temviriyanukul, P., & Suttisansanee, U. (2020). Investigation Of Anthocyanidins And Anthocyanins For Targeting Α-Glucosidase In Diabetes Mellitus. Preventive Nutrition And Food Science, 25(3), 263.
Raj, R., Shams, R., Pandey, V. K., Dash, K. K., Singh, P., & Bashir, O. (2023). Barley Phytochemicals And Health Promoting Benefits: A Comprehensive Review. Journal Of Agriculture And Food Research, 14, 100677.
Reid, L., Baxter, F., & Forbes, S. (2021). Effects Of Islet Transplantation On Microvascular And Macrovascular Complications In Type 1 Diabetes. Diabetic Medicine, 38(7), E14570.
Sarfraz, M., Khaliq, T., Hafizur, R. M., Raza, S. A., & Ullah, H. (2021). Effect Of Black Pepper, Turmeric And Ajwa Date On The Endocrine Pancreas Of The Experimentally Induced Diabetes In Wister Albino Rats: A Histological And Immunohistochemical Study. Endocrine And Metabolic Science, 4, 100098.
Shvachko, N. A., Loskutov, I. G., Semilet, T. V, Popov, V. S., Kovaleva, O. N., & Konarev, A. V. (2021). Bioactive Components In Oat And Barley Grain As A Promising Breeding Trend For Functional Food Production. Molecules, 26(8), 2260.
Sivieri, K., De Oliveira, S. M., De Souza Marquez, A., Pérez-Jiménez, J., & Diniz, S. N. (2022). Insights On Β-Glucan As A Prebiotic Coadjuvant In The Treatment Of Diabetes Mellitus: A Review. Food Hydrocolloids For Health, 2, 100056.
Solikhah, T. I., Wijaya, T. A., Asdiyanta, A. N., & Hamonangan, J. M. (2022). Histopathological Pancreas Analysis Of Hylocereus Polyrhizus Peel Ethanolic Extract On Alloxan Induced Diabetic Mice. Journal Of Drug Delivery And Therapeutics, 12(5), 149–152.
Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., Stein, C., Basit, A., Chan, J. C. N., & Mbanya, J. C. (2022). IDF Diabetes Atlas: Global, Regional And Country-Level Diabetes Prevalence Estimates For 2021 And Projections For 2045. Diabetes Research And Clinical Practice, 183, 109119
Published
Issue
Section
License
Copyright (c) 2024 Celin, Meldawati, Yeni Halim
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
