Pathogenesis and Diagnostic Challenges of Mucormycosis
DOI:
https://doi.org/10.59188/eduvest.v4i6.1474Keywords:
Mukormikosis, Mucorales, NetworkAbstract
Mucormycosis is a fungal infection caused by the order Mucorales from the class Zygomycetes. Among the genera within the order Mucorales, Rhizopus sp. is the genus most frequently causing infections. Mucorales fungi enter the human body in three ways: through inhalation of airborne spores, through broken skin, and through ingestion of contaminated food. Within the human body, the process is angioinvasive, leading to thrombosis and resulting in tissue necrosis. Currently, establishing a diagnosis is crucial for determining the patient’s prognosis, as it can reduce morbidity and mortality. The current diagnostic modes include direct examination, culture, histopathology, and molecular identification. Each of these methods has its advantages and disadvantages. However, for rapid diagnosis, molecular examination, either through PCR or RT PCR, is necessary.
References
Petrikkos G, Skiada A, Lortholary O, Roilides E, Walsh TJ, Kontoyiannis DP. Epidemiology and clinical manifestations of mucormycosis. Clinical Infectious Diseases. 2012;54(suppl_1):S23-S34.
Scherer E, Iriart X, Bellanger AP, Dupont D, Guitard J, Gabriel F, et al. Quantitative PCR (qPCR) detection of Mucorales DNA in bronchoalveolar lavage fluid to diagnose pulmonary mucormycosis. J Clin Microbiol. 2018;56(8).
Cornely O, Arikan‐Akdagli S, Dannaoui E, Groll A, Lagrou K, Chakrabarti A, et al. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013. Clin Microbiol Infect. 2014;20:5-26.
Walther G, Wagner L, Kurzai O. Updates on the taxonomy of Mucorales with an emphasis on clinically important taxa. J Fungi. 2019;5(4):106.
Afroze SN, Korlepara R, Rao GV, Madala J. Mucormycosis in a diabetic patient: A case report with an insight into its pathophysiology. Contemp Clin Dent. 2017;8(4):662.
Afroze SN, Korlepara R, Rao GV, Madala J. Mucormycosis in a diabetic patient: A case report with an insight into its pathophysiology. Contemporary clinical dentistry. 2017;8(4):662.
Petrikkos G, Tsioutis C. Recent advances in the pathogenesis of mucormycoses. Clin Ther. 2018;40(6):894-902.
Pongas G, Lewis R, Samonis G, Kontoyiannis D. Voriconazole‐associated zygomycosis: a significant consequence of evolving antifungal prophylaxis and immunosuppression practices? CMI. 2009;15:93-7.
Vijayabala GS, Annigeri RG, Sudarshan R. Mucormycosis in a diabetic ketoacidosis patient. Asian Pac J Trop Biomed. 2013;3(10):830-3.
Rammaert B, Lanternier F, Poirée S, Kania R, Lortholary O. Diabetes and mucormycosis: a complex interplay. Diabetes & metabolism. 2012;38(3):193-204.
Ibrahim AS, Spellberg B, Walsh TJ, Kontoyiannis DP. Pathogenesis of mucormycosis. Clinical Infectious Diseases. 2012;54(suppl_1):S16-S22.
Waldorf A, Ruderman N, Diamond R. Specific susceptibility to mucormycosis in murine diabetes and bronchoalveolar macrophage defense against Rhizopus. The Journal of clinical investigation. 1984;74(1):150-60.
Ibrahim A, Spellberg B, Edwards Jr J. Iron Acquisition: a novel prospective on mucormycosis pathogenesis and treatment. Current opinion in infectious diseases. 2008;21(6):620.
Liu M, Spellberg B, Phan QT, Fu Y, Fu Y, Lee AS, et al. The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice. The Journal of clinical investigation. 2010;120(6):1914-24.
Ghuman H, Voelz K. Innate and adaptive immunity to Mucorales. Journal of Fungi. 2017;3(3):48.
Thanh N, Rombouts F, Nout M. Effect of individual amino acids and glucose on activation and germination of Rhizopus oligosporus sporangiospores in tempe starter. Journal of applied microbiology. 2005;99(5):1204-14.
Lambrecht B, Prins B, Hoogsteden H. Lung dendritic cells and host immunity to infection. European Respiratory Journal. 2001;18(4):692-704.
Hassan MIA, Voigt K. Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors. Medical mycology. 2019;57(Supplement_2):S245-S56.
Ibrahim IM, Abdelmalek DH, Elfiky AA. GRP78: A cell's response to stress. LIfe Sci. 2019;226:156-63.
Quinones QJ, Ridder GGd, Pizzo SV. GRP78, a chaperone with diverse roles beyond the endoplasmic reticulum. Histol Histopathol. 2008.
Chamilos G, Lewis RE, Kontoyiannis DP. Delaying amphotericin B–based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis. Clinical Infectious Diseases. 2008;47(4):503-9.
Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clinical Infectious Diseases. 2005;41(5):634-53.
Spellberg B, Edwards J, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol. 2005;18(3):556-69.
Binder U, Maurer E, Lass‐Flörl C. Mucormycosis–from the pathogens to the disease. Clin Microbiol Infect. 2014;20:60-6.
Geramizadeh B, Modjalal M, Nabai S, Banani A, Forootan HR, Hooshdaran F, et al. Gastrointestinal zygomycosis: a report of three cases. Mycopathologia. 2007;164(1):35-8.
Badiee P, Arastefar A, Jafarian H. Comparison of histopathological analysis, culture and polymerase chain reaction assays to detect mucormycosis in biopsy and blood specimens. Iran J Microbiol. 2013;5(4):406.
Adawiyah R. Mukormikosis. JKK (Jurnal Kedokteran Klinik). 2018;1(3):65-8.
Chayakulkeeree M, Ghannoum M, Perfect J. Zygomycosis: the re-emerging fungal infection. European Journal of Clinical Microbiology and Infectious Diseases. 2006;25(4):215-29.
Wickes BL, Wiederhold NP. Molecular diagnostics in medical mycology. Nat Commun. 2018;9(1):1-13.
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