Case Report: Multiple Liver Nodules Due to Type 2 Diabetes Mellitus in a 55-Year-Old Male Patient

Authors

  • Billy Oktavian Fakultas Kedokteran Universitas Tarumanagara, Jakarta, Indonesia
  • Cristina Tarigan Bagian Ilmu Penyakit Dalam, Rumah Sakit Umum Daerah Ciawi, Indonesia

DOI:

https://doi.org/10.59188/eduvest.v4i5.1262

Keywords:

Hepatic Cirrhosis, Diabetes Mellitus, Liver Nodules, Case Report

Abstract

Hepatic cirrhosis is characterized by fibrosis and formation of liver nodules caused by chronic injury, causing changes in the normal lobular organization of the heart. Hepatic cirrhosis can occur in all genders and about two-thirds occurs in men and one part in women. Diabetic patients can experience insulin resistance, which can be the basis for the development of complications into liver cirrhosis. This case study describes a 55 year old male patient who was diagnosed with hepatic cirrhosis with diabetes mellitus and discussed the course of the disease to the therapy given to the patient. A 55 year old male patient came with complaints of shortness of breath that had been felt for 3 months before entering the hospital. Based on the history, physical examination and search, the patient was diagnosed with liver cirrhosis, multiple liver nodules, type 2 diabetes mellitus and pulmonary tuberculosis. Hepatic cirrhosis can be caused by various diseases, one of which is diabetes mellitus. Diabetes can progress to nonalcoholic fatty liver disease and eventually to cirrhosis and hepatocellular carcinoma. Insulin resistance syndrome is the main factor that can cause cirrhosis in diabetes patients. Early diagnosis, resistance and control of risk factors as well as appropriate treatment also play an important role in reducing the damage to the prognosis of patients with hepatic cirrhosis due to diabetes mellitus.

References

Asdie, R. H., Witjaksono, D. P., & Loehoeri, S. (2017). Buku Ajar Ilmu Penyakit Dalam. Interna Publishing.

Cheemerla, S., & Balakrishnan, M. (2021). Global Epidemiology of Chronic Liver Disease. Clinical Liver Disease. https://doi.org/10.1002/CLD.1061

Coman, L. I., Coman, O. A., Bădărău, I. A., Păunescu, H., & Ciocîrlan, M. (2021). Association between Liver Cirrhosis and Diabetes Mellitus: A Review on Hepatic Outcomes. Journal of Clinical Medicine 2021,. https://doi.org/10.3390/JCM10020262

Elkrief, L., Rautou, P. E., Sarin, S., Valla, D., Paradis, V., & Moreau, R. (2016). Diabetes mellitus in patients with cirrhosis: clinical implications and management. Liver International. https://doi.org/10.1111/LIV.13115/SUPPINFO

Garcia-Compean, D., Jacquez-Quintana, J. O., Gonzalez-Gonzalez, J. A., & Maldonado-Garza, H. (2009). Liver cirrhosis and diabetes: Risk factors, pathophysiology, clinical implications and management. World Journal of Gastroenterology. https://doi.org/10.3748/wjg.15.280

Huang, D. Q., Terrault, N. A., Tacke, F., Gluud, L. L., Arrese, M., Bugianesi, E., & Loomba, R. (2023). Global epidemiology of cirrhosis — aetiology, trends and predictions. Nature Reviews Gastroenterology & Hepatology 2023. https://doi.org/10.1038/s41575-023-00759-2

Jameson, Fauci, Kasper, Hauser, Longo, L. (2019). Harrison’s Principles of Internal Medicine. Mc Graw Hill Education.

Kementerian Kesehatan RI. (2022). Direktorat Pencegahan dan Pengendalian Penyakit Menular Kementerian Kesehatan. The Acceptance of Islamic Hotel Concept in Malaysia: A Conceptual Paper.

Li, X., Jiao, Y., Xing, Y., & Gao, P. (2019). Diabetes Mellitus and Risk of Hepatic Fibrosis/Cirrhosis. BioMed Research International. https://doi.org/10.1155/2019/5308308

PERKENI. (2019). Pedoman Pengelolaan dan Pencegahaan DM Tipe 2 Dewasa Indonesia. Perkumpulan Endokrinologi Indonesia, 113.

Ramachandran, T. M., Rajneesh, A. H. R., Zacharia, G. S., & Adarsh, R. P. (2017). Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo? Journal of Clinical and Diagnostic Research : JCDR. https://doi.org/10.7860/JCDR/2017/30705.10529

Rao, P. N. (2014). Nodule in Liver: Investigations, Differential Diagnosis and Follow-up. Journal of Clinical and Experimental Hepatology. https://doi.org/10.1016/J.JCEH.2014.06.010

Schuppan, D., & Afdhal, N. H. (2008). Liver Cirrhosis. Lancet. https://doi.org/10.1016/S0140-6736(08)60383-9

Sharma, B., & John, S. (2022). Hepatic Cirrhosis. Medicine (Spain). https://doi.org/10.1016/j.med.2020.04.001

Suva, M. (2014). A Brief Review on Liver Cirrhosis: Epidemiology, Etiology, Pathophysiology, Symptoms, Diagnosis and Its Management. Molecular Pharmacology.

Downloads

Published

2024-05-25